Small intestinal bacterial overgrowth (SIBO) is a digestive condition where there is too much bacteria in your small intestine, triggering symptoms including painful bloating and stomach distention, gas, diarrhea, among others. SIBO can be addressed in several ways, including antibiotics, antimicrobials, and specialized diet protocols, though it can take several rounds of treatment to get relief. Functional medicine doctors will look for the root cause (there are many) and individualize your treatment with the goal of relieving your symptoms–and preventing flare-ups in the future.
The acronym SIBO stands for “small intestinal bacterial overgrowth,” and it’s a digestive condition that happens when bacteria grow out of control in your small intestine. This can cause quite a few problems, including inflammation and immune system dysregulation. Those, in turn, can give rise to common symptoms like bloating, abdominal pain, diarrhea and/or constipation.
This underrecognized—and often ignored—condition has been slowly gaining attention. The problem is, SIBO can go undiagnosed or be mistakenly diagnosed as something else. Here’s what you need to know about what SIBO is, its potential symptoms, and the best treatment options to help you feel better again.
What is SIBO?
SIBO is a condition where bacteria from your colon (your large intestine) ends up in the small intestine—yep, where it’s not supposed to be. “The small intestine is not supposed to be sterile, but it’s also not supposed to have much bacteria,” says Kaytee Hadley, RDN, IFMCP, a functional medical nutritionist who specializes in GI conditions including SIBO. That bacteria then ferments food that passes into your small intestine, creating gasses that are responsible for triggering your symptoms.

SIBO is a complex condition with multiple potential causes. Some of the causes of SIBO include:
- Aging
- Biochemical imbalances
- Certain medications like proton pump inhibitors (PPIs), opioids, and antibiotics. (Broad-spectrum antibiotics can kill both good and bad bacteria, causing an imbalance in the gut microbiota.)
- Digestive system dysfunction, which includes diseases like irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and celiac disease.
- Food poisoning
- Immune system factors like common variable immunodeficiency
- Impaired intestinal motility (which allows bacteria to multiply and migrate), including gastroparesis, scleroderma, and diabetes.
- Lifestyle factors, including stress, poor diet high in refined carbohydrates, and alcohol consumption.
- Low stomach acid, which reduces the body’s ability to moderate bacterial growth.
- Pancreatic insufficiency and chronic pancreatitis
- Prior gastrointestinal surgeries
- Structural abnormalities, such as small bowel diverticula, blind intestinal loops, adhesions and strictures, and ileocecal valve impairment. (These can create pockets where bacteria accumulate and disrupt normal flow.)